| abstract |
Disclosed herein are methods for preventing, delaying, or treating cancer in an individual, the method comprising administering a PARP inhibitor, specifically (R) -2-fluoro-10a-methyl-7, to an individual in need thereof , 8,9,10,10a, 11-hexahydro-5,6,7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluorene-4 (5H) -one, its sesquihydrate Or a pharmaceutically acceptable salt thereof in combination with temozolomide and / or radiation therapy. In addition, a pharmaceutical combination and a use thereof are disclosed. The pharmaceutical combination contains a PARP inhibitor, specifically (R) -2-fluoro-10a-methyl-7,8,9,10,10a, 11-hexahydro-5, A combination of 6,7a, 11-tetraazacyclohepta [def] cyclopenta [a] pyrene-4 (5H) -one, a sesquihydrate or a pharmaceutically acceptable salt thereof, and temozolomide. |