| abstract |
The present invention relates to pyrimidine derivatives of formula (I), Where (R 1 ) n , R 3 , R 4a , R 4b , R 5a , R 5b and Ar 1 are as described in this specification and they are treated by modulating the immune response including the reactivation of the immune system in the tumor Use of cancer. The present invention also relates to novel benzofuran and benzothiophene derivatives of formula (II) and their use as medicaments, their preparation methods, their pharmaceutically acceptable salts and their use as medicaments, containing one or Various pharmaceutical compositions of compounds of formula (I) and in particular their use as modulators of the prostaglandin 2 receptor EP2 and / or EP4. |