| abstract |
The present invention provides a single-stranded oligonucleotide that can be easily manufactured in order to efficiently control a target gene. The single-stranded oligonucleotide of the present invention is a single-stranded oligonucleotide in which X and Y represented by formula (I) hybridize at a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified nucleotide, and has a first nucleotide sequence capable of hybridizing with a second oligonucleotide. Y is composed of 4 to 100 nucleotides, and can be hybridized with the first oligonucleotide, and has a second nucleotide sequence containing at least one ribonucleotide. At least one of the nucleotide sequences X, Xz, and Y is an antisense sequence having hybridization with a target RNA. At least one of L, Lx, and Ly is a linker containing a non-nucleotide structure. |