| abstract |
The present invention relates to a conjugate or a pharmaceutically acceptable salt thereof, the conjugate comprising a GLP-1 / glucagon receptor agonist, a linker and a transparent having -L 1 -L 2 -LYR 20 group Hyaluronic acid hydrogel, where Y represents the GLP-1 / glucagon receptor agonist portion; and -L is the linker portion of formula (Ia), Among them, the dotted line indicates the connection of one of the amine groups of the GLP-1 / glucagon receptor agonist portion by forming an amide bond. The invention further relates to a pharmaceutical composition comprising the conjugate, and its use as a medicament for the treatment or prevention of diseases or conditions treatable by GLP-1 / glucagon receptor agonists. |