| abstract |
This application relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido [3,4-b] indoles of formula I, n n n Where A, E, G, R 1 to R 6 and R 10 are as defined in the claim, which stimulate chondrogenesis and cartilage matrix synthesis and can be used to treat cartilage disorders and conditions in which regeneration of damaged cartilage is desired, such as joint diseases Such as osteoarthritis. The present application also relates to methods for synthesizing compounds of formula I, their use as medicaments, and pharmaceutical compositions containing them. |