| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_006e91eddabe95ad7aa889123d31cb9a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-62 |
| filingDate |
2017-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e54879a3c0db6421b6515595931e233a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e824bfbd918c1f9d585a5146d505312 |
| publicationDate |
2018-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-201822819-A |
| titleOfInvention |
Selective sulfonation of benzodiazepine derivatives |
| abstract |
The present invention relates to a novel method for preparing a cell-binding agent-cytotoxic agent conjugate, wherein the cytotoxic agent is an imine-containing cytotoxic agent with a cis-butene diimide group. In some embodiments, the cell-binding agent (CBA) passes through a position in position 442 (or C442) corresponding to EU / OU number on the antibody CBA through an engineered Cys, such as engineered Cys in the heavy chain CH3 domain. Covalently attached to the cytotoxic agent. The present invention also provides conjugates prepared by the methods of the present invention, and compositions and methods useful for using the conjugates of the present invention to inhibit abnormal cell growth or treat proliferative disorders in mammals. |
| priorityDate |
2016-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |