| abstract |
Provided is a medicine / cancer treatment method in which a compound having MDM2 inhibitory activity and a DNA methyltransferase inhibitor are combined.n n n Provide a combination of (3'R, 4'S, 5'R) -N-[(3R, 6S) -6-aminomethylmethyltetrahydro-2H-piperan-3-yl] -6 "-chloro-4 ' -(2-chloro-3-fluoropyridin-4-yl) -4,4-dimethyl-2 "-pendant oxygen-1", 2 "-dihydrobisspiro [cyclohexane-1,2 ' -Pyrrolidine-3 ', 3 "-indole] -5'-formamidine or a pharmaceutically acceptable salt thereof and a DNA methyltransferase inhibitor, a medicine or a combination treatment method. |