| abstract |
Disclosed herein are pharmaceutical compositions comprising antibodies or antigen-binding fragments that bind to Globo H, stage-specific embryonic antigen 3 (SSEA-3), and stage-specific embryonic antigen 3 (SSEA-4), The method of using the composition is disclosed. Methods of use include, but are not limited to, cancer treatment and detection. The antibodies disclosed herein can bind to the surface of specific cancer cells. Exemplary binding targets for antibodies disclosed herein include epithelial cancer (carcinoma), such as sarcoma, skin cancer, blood cancer, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head and neck Cancer, nasopharyngeal cancer, esophageal cancer, gastric cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, bowel cancer, colorectal cancer, kidney cancer, cervical cancer, endometrial cancer, ovarian cancer, testicular cancer , Cheek cancer, oropharyngeal cancer, laryngeal cancer, and prostate cancer. |