| abstract |
Compounds of formula I are provided: Or its mirror image isomer, its metabolite, its derivative, its deuterated derivative, its halogenated derivative, its prodrug, its pharmaceutically acceptable salt, its N-oxide, or a combination thereof, its preparation The methods and intermediates used, their compositions, and their uses. A pharmaceutical composition comprising a compound of formula I and a compound of formula II: Or its mirror image isomer, its metabolite, its derivative, its deuterated derivative, its prodrug, its pharmaceutically acceptable salt, its N-oxide, or a combination thereof. A composition and method for improving the efficacy of DEX, or providing a beneficial pharmacokinetic effect to DEX, comprising co-administration of a compound of formula I or SARPO, and a compound of formula II or DEX to an individual in need thereof, and its dosage form, Drug delivery system, treatment method. |