| abstract |
The object of the present invention is to provide a compound which can promote angiogenesis by inhibiting the function of TSP1 and is useful for the treatment or prevention of diseases such as severe lower limb ischemia.n n n The solution is a macrocyclic polypeptide represented by formula (I) or its pharmacologically acceptable salt, etc., n n n [In the formula, A is selected from linking groups A 1 to A 6 , X aa1 is an aliphatic amino acid, aromatic amino acid, basic amino acid, neutral amino acid, or acidic amino acid residue Xaa2 is the residue of aromatic amino acid or neutral amino acid; X aa3 is the residue of aliphatic amino acid, aromatic amino acid, or basic amino acid; X aa4 is Ser, Thr, Ala, or m S; X aa5 is Gly or Ser; X aa6 is the residue of a basic or neutral amino acid; X aa7 is a neutral or acidic amino acid X aa8 is aromatic amino acid residue; X aa9 is aliphatic amino acid, neutral amino acid, or aromatic amino acid residue; X aa10 is basic amino acid, fat Aminic amino acid, aromatic amino acid, or neutral amino acid residue; X aa11 is an aromatic amino acid residue; X aa12 is an aliphatic amino acid, aromatic amino acid, or basic Amino acid residues]. |