abstract |
The present invention relates to a heterocyclic compound of formula (I), All the variables are as defined in the specification; they can regulate the activity of CFTR. The present invention further provides methods of making the compounds of the present invention and their therapeutic uses. The present invention further provides methods for preparing these compounds, their other medical uses, specifically their use for the treatment and management of diseases or disorders (including cystic fibrosis and related disorders). |