abstract |
A compound is disclosed which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithio-5,6,12,13,22-pentaza Heptane [27.7.1.1 4,7 .0 11,15 .0 16,21 .0 20,24 .0 30,35 ] Thirty-eight carbon-1 (37), 4 (38), 6,11,14 , 16,18,20,23,29,31,33,35-tridecene-23-carboxylic acid (chemical formula I) And its mirror image isomers and pharmaceutically acceptable salts. It also revealed 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithio-5,6,12,13,22-pentazaazaheptane ring [27.7. 1.1 4,7 .0 11,15 .0 16,21 .0 20,24 .0 30,35 ] Thirty-eight carbon-1 (37), 4 (38), 6,11,14,16,18, 20,23,29,31,33,35-tridecene-23-carboxylic acid pharmaceutical compositions and their enantiomers and pharmaceutically acceptable salts, and methods of using such compounds and compositions to treat cancer. |