| abstract |
Provided is a method for improving the skin retentivity of a compound effective in preventing or improving skin aging. Oil of the present invention containing 1) a compound represented by the following general formula (1), its isomers and / or pharmacologically acceptable salts thereof, and 2) a partially crosslinked methyl polysiloxane The external preparation for skin in the form of an oil gel enables the active ingredients of the above 1) to easily move from the preparation to the skin, and at the same time improves the skin absorbency and improves the skin retention.nn n n n n n n n n n [In the formula, R 1 represents a linear or branched alkyl group having 1 to 4 carbon atoms substituted by a carboxyl group, or a carbon number 1 substituted by a carboxylic acid ester group having an alkyl chain having 1 to 4 carbon atoms. ~ 4 is a straight or branched alkyl group, and R 2 and R 3 each independently represent a straight or branched alkyl group having 1 to 4 carbon atoms. ] |