| abstract |
The present invention provides chimeric compounds that modulate protein function to restore protein homeostasis (including interleukin, aiolos and/or ikaros activity, TNF-α activity, CK1-α activity, and cells). Cell adhesion). The invention provides methods of modulating a protein-mediated disease, such as a cell-mediated disease, disorder, condition or response. The invention provides compositions comprising combinations with other interleukins and inflammatory mediators. Provided herein are methods of treating, ameliorating or preventing protein-mediated diseases, disorders, and conditions. |