| abstract |
The present application relates to a compound of formula (I), wherein R1 and R2 represent hydrogen or a halogen atom; R3 represents a hydrogen atom or a -COOH, -OH or -OPO(OH)2 group; R4 represents a hydrogen atom or a fluorine atom; and R5 represents hydrogen. An atom or an -OH group; wherein at least one of R3 or R5 is not a hydrogen atom; when R3 represents a -COOH, -OH or -OPO(OH)2 group, R5 represents a hydrogen atom; and when R5 represents an -OH group When R3 and R4 represent a hydrogen atom; and R6 is selected from an optionally substituted phenyl group, heteroaryl group, cycloalkyl group or heterocycloalkyl group. The present application also relates to the preparation of compounds of formula (I) and their use as estrogen receptor inhibitors and degrading agents, in particular for the treatment of cancer. |