http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-201736394-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2cd21ed4492119e6ec9d0c2bf7451b0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-79 |
| filingDate | 2016-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14be5a63b09dfac7e9406fb759715001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47b5567449e6fdae76bda13cb3d7dce6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c5026cf3dcbc5f9be29fd22068b32e4 |
| publicationDate | 2017-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-201736394-A |
| titleOfInvention | Entity entanglement of artificial transcription factors |
| abstract | Delivery of artificial transcription factors into cells via protein transduction is promising for the development of novel therapeutics. However, conventional protein transduction has problems with poor endosomal escape and subsequent degradation of the artificial transcription factor protein by endosomes. Much of this is due to endosomal entanglement, which limits the artificial transcription factor to the endosomal membrane, thereby interfering with transport to other secondary cell locations. The present invention relates to endosomal de-entanglement, and subsequent endosomal escape enhancement, by incorporating a specific endosomal protease incision site into the artificial transcription factor protein to overcome endosomal entanglement. |
| priorityDate | 2016-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1868.