abstract |
A compound of formula I: □ or a stereoisomer, tautomer or pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R1, R2, Ra, Rb, Rc, Rd, X, Y, B And Ring C is as defined herein, and wherein the YB moiety and the NH-C(=X)-NH moiety are in a trans configuration, the compound is a TrkA kinase inhibitor and is useful for treating diseases treatable with a TrkA kinase inhibitor, such as Pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases. |