| abstract |
The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, nucleic acids encoding the antibodies, and methods of obtaining such antibodies. The invention further relates to methods of treatment using such antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of conditions associated with CXCR4 function or performance (eg, cancer), such as colon cancer, RCC, esophageal cancer, gastric cancer, head and neck Cancer, lung cancer, ovarian cancer, pancreatic cancer or blood cancer. |