| abstract |
The present invention relates to a compound of formula (XI): wherein R1a, R2a, R3a, R4a, R5a, R6a, and Aa are as defined herein, and a pharmaceutically acceptable salt thereof. The compounds of the invention are hematopoietic prostaglandin D synthetase (H-PGDS) inhibitors and are useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention further relates to a pharmaceutical composition comprising a compound of the invention. The invention still further relates to a method of inhibiting H-PGDS activity and treating a condition associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. |