| abstract |
The present invention provides synthetic, pharmaceutically acceptable formulations and uses of a compound of Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. □ With respect to the compound of formula I, X, Y, R1, R2, R3a, R3b, R4a, R4b and R5 are as defined in the specification. The compounds of formula I of the present invention are inhibitors of eIF4A and are useful in a variety of therapeutic applications including, but not limited to, the treatment of inflammation and various cancers. |