| abstract |
The present invention provides an antibody-cytokine implant composition comprising, for example, binding to a member of the interleukin receptor superfamily (ie, IL10R1) and stimulating intracellular signaling by means of a member of the interleukin receptor superfamily and An implanted structure that stimulates signal transmission. The compositions provided find use for enhancing anti-inflammatory cell responses and relatively reducing the pro-inflammatory effects that can counteract the immune-related conditions in therapy, amelioration and prevention by potentiating anti-inflammatory responses. The invention further provides polynucleotides and vectors encoding such molecules, and host cells capable of producing the molecules, as well as methods of making and using the compositions. |