| abstract |
The present invention relates to a porphyrin-2-one derivative of the formula: □ wherein the substituent is as defined in claim 1. These compounds are useful in the treatment of CNS diseases associated with schizophrenia-positive (psychotic) and negative symptoms, drug abuse, alcohol and drug addiction, obsessive-compulsive disorder, cognitive impairment, bipolar disorder, mood disorders, major depression, and therapeutic resistance. Sexual depression, anxiety, Alzheimer's disease, autism, Parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleep disorder, chronic fatigue syndrome , stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, effects of arthritis, autoimmune diseases, viral and fungal infections, cardiovascular disease, ophthalmology and inflammatory retina Disease and balance problems, epilepsy and neurodevelopmental disorders with complications of epilepsy. |