| abstract |
The present invention provides novel lipids and compositions involving such novel lipids. Nanoparticle compositions include novel lipids as well as other lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further comprising a therapeutic and/or prophylactic agent such as RNA are suitable for delivery of a therapeutic and/or prophylactic agent to a mammalian cell or organ, for example, to modulate polypeptide, protein or gene expression. |