| abstract |
The present invention provides a method of inhibiting or attenuating tumor growth in an individual by administering an IL-6 antagonist to the individual. In certain embodiments, the methods of the invention are used to inhibit the growth of anti-VEGF-resistant tumors in an individual. The IL-6 antagonist can be, for example, an antibody that specifically binds to IL-6R. The IL-6 antagonist can be administered in combination with a VEGF antagonist, and/or an EGFR antagonist, and/or an ErbB3 antagonist. |