| abstract |
The present invention relates to a compound of formula Inâ–ˇ wherein R1' is CH3; R1 is methyl, ethyl, CF3, CH2OH, cyclopropyl or cyano, or R1' and R1 together form 1,1-dioxy-tetrahydro-thiophene-3- Base ring; R2 is hydrogen, methyl, ethyl, isopropyl, tert-butyl, cyclopropyl, hydroxymethyl or 2-propyl-2-ol; R3 is Cl, F, CF3, methyl, Methoxy, isopropyl, cyano or cyclopropyl; R4 is hydrogen, methyl, F or Cl; or a pharmaceutically acceptable salt or acid addition salt, relating to a racemic mixture Or with respect to their corresponding enantiomers and/or optical isomers and/or their stereoisomers.nThe compounds of formula I are useful in the treatment of psychiatric disorders such as schizophrenia, bipolar disorder, obsessive-compulsive disorder or autism disorders. |