| abstract |
The present invention relates to antibodies and fragments thereof which are immunoreactive to mammalian B7-H3 receptors and more particularly to human B7-H3 receptors, and to their use, in particular in the treatment of cancer and inflammation . The invention therefore specifically relates to humanized B7-H3 reactive antibodies and immunoreactive fragments thereof, which are capable of mediating, and better enhancing, the immune system against cancer cells associated with a variety of human cancers Activation. |