| abstract |
The present invention discloses compositions and methods related or derived from anti-JAG1 antibodies. More specifically, the present invention discloses fully human antibodies that bind to JAG1, JAG1 binding fragments and derivatives of such antibodies, and JAG1 binding polypeptides comprising such fragments. Further, the present invention discloses nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides; cells comprising the same; methods of preparing such antibodies, antibody fragments and derivatives and polypeptides; and using such antibodies Methods of antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing an individual having a JAG1-related disorder or condition. Also disclosed is a treatment for JAG1 expressing tumors (including hepatocellular carcinoma and squamous carcinoma) and non-neoplastic diseases (selected from the group consisting of rheumatoid arthritis, experimental lung injury, atherosclerosis, hepatitis C) A method of virus-induced chronic liver disease, ischemic myocardial damage, and heart failure. |