| abstract |
The present invention provides topical compositions and methods of making and using the same. In the first aspect, the topical composition comprises minocycline, magnesium salt and sulfite in a non-aqueous solvent. In still another aspect, the topical composition comprises a tetracycline drug, a magnesium source, an aliphatic monohydric alcohol, and a polyol, wherein (i) the ratio between the aliphatic monohydric alcohol and the propylene glycol is 1 by weight. The range of 1 to 99:1, and (ii) the tetracycline drug is dissolved in the topical composition. |