| abstract |
Methods of isolating and purifying antibodies are disclosed herein, wherein an affinity chromatography step is used to produce an antibody composition of sufficient purity for medical use. The methods described herein include pH virus reduction/deactivation, ultrafiltration/diafiltration, affinity chromatography (preferably protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Additionally, the invention relates to pharmaceutical compositions comprising one or more antibodies of the invention. |