| abstract |
The present invention provides a compound of formula (I),nâ–ˇnCompositions comprising such compounds; the use of such compounds in therapy (e.g., in the treatment or prevention of a disease or condition involving plasma kallikrein activity; and methods of treating a patient with such compounds; wherein R5, R6, R7, A, B, U, D, E, W, X, Y and Z are as defined herein. |