| abstract |
An antibody that immunospecifically binds to CD123 is provided herein. Also described are related polynucleotides encoding the provided CD123-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, and associated vectors and detectably labeled antibodies or antigen-binding fragments . In addition, methods of using the provided antibodies are described. For example, the antibodies provided can be used to diagnose, treat, or monitor the progression, regression, or stabilization of a CD123-expressing cancer; thereby determining whether the patient should be treated for cancer; or determining whether the subject has CD123-expressing cancer and is thus available with CD123 Specific anti-cancer therapeutics such as the multispecific antibodies directed against CD123 and CD3 described herein are used for treatment. |