| abstract |
This application provides a compound of formula (J),nâ–ˇnOr a pharmaceutically acceptable salt, isomer, tautomer or mixture thereof, wherein X, Y, Z, n, m', A', R1, R2 and R3 are as described herein. These compounds are inhibitors of the activity of phospholipid inositol 3-kinase (PI3K) and are useful in the treatment of conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt, isomer, tautomer or mixture thereof, and the use of such compounds and compositions for treatment by one or more A method of mediated by PI3K isoforms. |