| abstract |
The present disclosure provides compounds having a hydrophilic self-sacrificing linker that can be cleaved under suitable conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker comprising a thiol unit, an optional spacer unit for providing a spacing between the drug moiety and the targeting moiety, A cleavable peptide linker, a hydrophilic self-sacrificing linker, and optionally a second self-sacrificing spacer or a cyclized self-eliminating linker under appropriate conditions. In some aspects of the disclosure, the targeting moiety is an anti-HER2 antibody. |