| abstract |
The present invention provides a process for the preparation of a salt of AZD5363 or AZD5363 comprising: (a) 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-di Azaspiro[4.5]decane-2,4-dione:n□ or a salt thereof is reacted with (S)-3-amino-3-(4-chlorophenyl)propan-1-ol or a salt thereof in the presence of a base; and (b) AZD5363 is isolated or isolated as a salt. The present invention provides 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]nonane-2,4-dione and By cyclizing 4-(alkyloxycarbonylamino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)hexahydropyridine-4-carboxylic acid or a salt thereof The reagent reaction was carried out. |