abstract |
The present invention provides an antibody that specifically binds to a human glucocorticoid-inducible TNFR family-associated receptor (GITR) and a composition comprising the same. In a particular aspect, the antibody specifically binds to human GITR and modulates GITR activity, for example, using this antibody to enhance, activate or induce GITR activity. The invention also provides methods of treating diseases, such as cancer and infectious diseases, by administering antibodies that specifically bind to human GITR and modulate GITR activity (eg, enhance, activate or induce GITR activity). |