| abstract |
The present invention provides a novel 3-cyclic compound having JAK inhibitory activity, particularly for prevention, treatment or improvement of an autoimmune disease, an inflammatory disease, an allergic disease.nThe present invention provides a formula (I), formula (II) or formula (III) (A1, A2, A3 means cyclohexane-1,4-diyl, etc., L1, L2, L3 means methylene, etc. X1, X3 means O or NH, R1, R3 means cyano C1-6 haloalkyl, etc., R2 means a novel 3-ring compound represented by an aromatic heterocyclic group, a tautomer of the compound or Pharmaceutically acceptable salts or solvates thereof.n□ |