| abstract |
The present invention relates to porphyrin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives of the following formula:n□ wherein Ar1, Ar2, R1, R2, R3, X and n are as defined herein.nAnd pharmaceutically acceptable salts, racemic mixtures thereof or their corresponding mirror image isomers and/or optical isomers and/or stereoisomers for the treatment of certain central nervous system disorders, such central nervous systems Systemic disorders are positive (psychotic) and negative symptoms of schizophrenia, drug abuse, alcohol and drug addiction, obsessive-compulsive disorder, cognitive impairment, bipolar disorder, mood disorder, major depression, refractory depression, anxiety , Alzheimer's disease, autism, Parkinson's disease, chronic pain, borderline personality disorder, sleep disorders, chronic fatigue syndrome, stiffness, anti-inflammatory effects in arthritis And balance issues. |