| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55fa76c9b7175910a5bffb3e26fb5b2a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-624
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-626
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2809 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2014-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52b9d59657c44ae255d4306ae59e1a7c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a38941f8ee921b24c66739e6f05a799c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7980b3eadf6b71cf5828b1064f253cfa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19ec906fef7f297ffbce111d129e93f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b87089649461e613779d8b5de820a132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a32a4b4e94d00c6ba6f5ad536583e82b |
| publicationDate |
2016-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-201605895-A |
| titleOfInvention |
Bispecific monovalent diabodies capable of binding gpA33 and CD3 and uses thereof |
| abstract |
The present invention relates to a bispecific monovalent diabody comprising two polypeptide chains and having at least one binding site specific for the epitope of CD3 and a binding site specific for the epitope of gpA33 (ie, "gpA33" x CD3 bispecific monovalent diabodies"). The invention also relates to a bispecific monovalent diabody comprising an immunoglobulin Fc domain ("bispecific monovalent Fc diabody") and a binding site consisting of three polypeptide chains and having at least one epitope specific for gpA33 Point and a binding site specific for the CD3 epitope (ie, "gpA33 x CD3 bispecific monovalent Fc diabody"). Here, the bispecific monovalent diabody and the bispecific monovalent Fc diabody are capable of binding to both gpA33 and CD3. The present invention relates to pharmaceutical compositions comprising such bispecific monovalent diabody or such bispecific monovalent Fc diabody. The invention further relates to methods of using such diabodies to treat cancer and other diseases and conditions. |
| priorityDate |
2013-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |