| abstract |
The present invention provides a compound of formula (I):nâ–ˇnOr a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein all variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. The invention is also directed to pharmaceutical compositions comprising such compounds and methods of use thereof for treating thromboembolism and/or inflammatory conditions. |