| abstract |
An object of the present invention is to provide a mucosal vaccine composition which can be used as a prophylactic or therapeutic agent for infectious diseases or cancer, which can safely and effectively induce a systemic immune response and a mucosal immune response, and can be applied to the oral mucosa, the mucous membrane of the eye, Ear mucosa, genital mucosa, throat mucosa, tracheal mucosa, bronchial mucosa, lung mucosa, gastric mucosa, intestinal mucosa or rectal mucosa.nThe present invention relates to a mucosal vaccine composition characterized in that the pair is selected from the group consisting of oral mucosa, eye mucosa, auricular mucosa, genital mucosa, throat mucosa, tracheal mucosa, bronchial mucosa, lung mucosa, gastric mucosa of human or animal. At least one mucosal agent of the group consisting of intestinal mucosa and rectal mucosa, and comprising at least one antigen, and a lipopolysaccharide or a salt thereof derived from the following Gram-negative bacteria as an immunostimulating agent, the leather The Langer-negative bacteria are selected from the group consisting of Serratia, Leclercia, Rahnella, Acidical dus, Acidiphilium, and acid. Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Portuguese Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Parasiticus Paracraur "ococcus", Rhodobactern(Rhodopila), Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas , Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium At least 1 of a group consisting of Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter Kind. |