| abstract |
The present invention provides a compound useful as a therapeutic agent for breast cancer.nThe present inventors examined compounds having Complex I inhibition and AMPK activation, and confirmed that the bicyclic nitrogen-containing aromatic heterocyclic guanamine compound of the present invention has good Complex I inhibition and AMPK activation, and is not only A human PIK3CA mutant positive breast cancer cell line that does not exhibit MCT4, and has a cell proliferation inhibitory effect on a human breast cancer cell line that does not have a mutation of MCT4 and does not have a PIK3CA mutation, and a human PIK3CA mutation-positive breast cancer cell line MDA that does not exhibit MCT4 The -MB-453 cell-cancerous mouse showed an anti-tumor effect confirmation, and completed the present invention. The bicyclic nitrogen-containing aromatic heterocyclic guanamine compound of the present invention can be used as a breast cancer, particularly a breast cancer which does not exhibit MCT4, and is particularly useful as a therapeutic agent for PIK3CA mutation-positive breast cancer which does not exhibit MCT4. |