http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-201529857-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37c883250ee582bf8e0506905a302666 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2014-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7997a1805514feb4b13a08227deddc84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ea94b660583289e26b3525393c71c53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c06611156f20a8aefc393a6ce4e8d542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_042e7061fcd10f2878dd604749f9297f |
| publicationDate | 2015-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-201529857-A |
| titleOfInvention | A screening method for risk of toxicity caused by drugs |
| abstract | The present invention provides a screening method for the risk of toxicity caused by drugs such as anti-tuberculosis drugs, and the use of NAT2, CYP2E1, and Xanthine Oxidase genes to screen for toxicity caused by anti-tuberculosis drugs, particularly the risk of liver damage. The method of the present invention comprises providing a test subject, detecting at least one SNP genotype of the NAT2, CYP2E1, and Xanthine Oxidase genes in the genomic DNA of the sample, wherein the presence of the SNP genotype indicates that the test subject has an individual The risk of toxicity caused by the anti-tuberculosis drug; the SNP genotype is selected from at least one of the group consisting of rs1041983, rs1112005, rs1495741, rs1799930, rs1799931, rs1801280, rs1961456, rs2087852, rs11996129, rs2031920, Rs2249695, rs3813865, rs3813867, rs1884725, rs2295475 and rs17011368. Further, the method for screening for toxicity of a drug of the present invention comprises a test subject, wherein at least one SNP genotype of the Xanthine Oxidase gene in the genomic DNA of the sample is detected, wherein the SNP genotype exists, The subject is shown to be at risk of developing high uric acid and its associated disease risk; the SNP genotype is selected from at least one of the group consisting of rs1884725, rs2295475 and rs17011368. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I642784-B |
| priorityDate | 2014-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 159.