| abstract |
The present invention provides a boron-containing diindenyl quinone compound of formula I:nâ–ˇnAnd pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4 and R5 are as defined in the specification. The invention also provides the use of a boron-containing dimercaptopurine compound in an induced gene expression system based on an ecdysone receptor. Thus, the present invention can be used in applications where it is desirable to control the degree of gene expression: such as gene therapy, treatment of diseases, large-scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomic, Regulation of the metabolism of metabolomics and gene-transforming organisms. |