| abstract |
The invention provides antibodies, antigen-binding proteins and Fc-fusion proteins comprising a recombinant polypeptide that bind to a particular Fc receptor but have reduced effector function, the recombinant polypeptide comprising a chimeric heavy chain constant region sequence. The present invention provides a method of producing a construct for expressing the Fc-containing chimeric antibody, antigen-binding protein, and Fc-fusion protein in a cellular system, and a method of producing and liberating the Fc-containing chimeric protein. |