| abstract |
The present invention relates to an artificial transcription factor comprising a poly-finger zinc finger protein specific for a promoter region of a nuclear receptor gene fused to an inhibitory or activating protein domain, a nuclear localization sequence and a protein transduction domain. In a particular example, such promoter regions of the nuclear receptor gene modulate the expression of the glucocorticoid receptor, androgen receptor or estrogen receptor ESR1. Artificial transcription factors for this glucocorticoid receptor are useful for treating diseases mediated by glucocorticoids, such as inflammatory processes, diabetes, obesity, coronary artery disease, asthma, celiac disease, and lupus erythematosus. Artificial transcription factors for the androgen receptor are suitable for treating diseases modulated by steroids, such as various cancers, coronary artery diseases, metabolic disorders such as obesity or diabetes, or affective disorders such as schizophrenia, depression or attention Insufficient hyperactivity disorder). Artificial transcription factors directed to the estrogen receptor are useful for treating diseases modulated by estrogen, such as various cancers, cardiovascular diseases, osteoporosis or affective disorders. |