| abstract |
The present invention relates to the field of medicine, and discloses novel nitrogen heterocyclic derivatives, processes for their preparation and use as medicaments, especially as medicaments for the treatment and prophylaxis of tissue fibrotic diseases. The invention also discloses the use of a pharmaceutically acceptable pharmaceutical composition comprising the compound of the invention and the use of the composition thereof for treating a fibrotic disease in human or animal tissues, in particular in the treatment of human or animal renal interstitial fibrosis, glomeruli Hardening, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, skin fibrosis, postoperative adhesion, benign prostatic hypertrophy, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, liver Use in sclerosis, myofibrolysis, neurofibromatosis, pulmonary interstitial fibrosis, diabetic nephropathy, Alzheimer's disease or vascular fibrosis. |