abstract |
The present invention relates to a macrocyclic compound as a kinase inhibitor and a composition containing the same, particularly as an inhibitor of LRRK2 kinase, for use in the diagnosis, prevention and/or treatment of LRRK2 kinase-associated diseases. Furthermore, the invention provides methods of using the compounds, for example as a pharmaceutical or diagnostic agent. Finally, the invention also relates to novel macrocyclic compounds. |