| abstract |
The present invention discloses a process for the preparation of a compound of formula 1, wherein Q and Z are as defined in the present disclosure, the process comprising self-containing a compound of formula 2, a compound of formula 3, a base, and capable of forming a low boiling azeotrope with water. Water is distilled from a mixture of aprotic solvents comprising at least one selected from the group consisting of alkaline earth metal hydroxides of formula 4 (wherein M is Ca, Sr or Ba), and alkali metal carbonates of formula 4a (wherein M1 is Li, Na). Or a compound of the group consisting of K), 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene . □ The present invention also discloses a process for the preparation of a compound of formula 2, which process comprises (1) forming a reaction mixture comprising a Grignard reagent from a compound of formula 5 (wherein X is Cl, Br or I) is prepared by contacting magnesium metal or an alkyl magnesium halide in the presence of an ether solvent; and subsequently (2) contacting the reaction mixture with a compound of formula 6, wherein Y is OR11 or NR12R13, and R11, R12 and R13 are As defined in this disclosure. The invention further discloses a process for the preparation of a compound of formula 7 using a compound of formula 1, wherein Q and Z are as defined in the disclosure, the method being characterized by the preparation of a compound of formula 1 by the methods disclosed above or by use of The compound of formula 1 prepared by the process disclosed above. □ |