| abstract |
The present invention relates to a SEDDS or SMEDDS or SNEDDS formulation for drug delivery of a lipophilic therapeutic by using the therapeutic agent with a phytosterol and/or phytosterol ester, a hydrophobic surfactant, a hydrophilic surface The active agent, optionally with one or more solubilizing agents and/or one or more digestible oils, provides enhanced modulation of the solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of the therapeutic agent, thereby producing a cast The higher bioavailability of the therapeutic agent to the individual in need of the therapeutic agent. Also described herein are pharmaceutical compositions, methods of manufacture, and methods of using such formulations and pharmaceutical compositions. Formulations of the invention may be formulated to minimize the synthesis of dihydrocinone when the therapeutic agent comprises a testosterone or a ketosterone. |