| abstract |
The present invention provides a Bruton's tyrosine kinase (Btk) inhibitor (for example, 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazole) And [3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one) in combination with a CYP3A4 inhibitor. The invention also provides for administration of a Bruton's tyrosine kinase (Btk) inhibitor (eg, 1-((R)-3-(4-amino-3-(4-phenoxyphenyl))- Method for treating cancer and autoimmune disorders by combining 1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one with CYP3A4 inhibitor . |